Why do results with a smaller number of matched genes sometimes get high scores?

The matching score is positively affected by higher numbers of matched genes, but is also significantly influenced by three additional parameters:

• The specific annotations of the matched genes (see annotation details). ‘Specific’, ‘enriched’ and ‘selective’ annotations increase the gene score, while ‘abundant’ and’ housekeeping’ annotations decrease it.
• The total number of genes in the entity: there is a negative effect of a high total number of genes in the entity on the match score.
• The entity type: genes in large scale data set samples have lower scores when compared to genes in other entities.